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- 规格参数
- 包装参数
Biochem/physiol Actions
ZM323881 is also known as (5‐{[7‐(benzyloxy) quinazolin‐4‐yl]amino}‐4‐fluoro‐2‐methylphenol). It is capable of blocking the efflux function and altering breast cancer resistant protein (BCRP)-related multidrug resistance (MDR).
ZM323881 is a selective inhibitor of VEGFR-2 with an IC50 value of 2 nM. ZM323881 is selective for VEGFR-2 over VEGFR-1 and other receptor tyrosine kinases including PDGFRβ, FGFR1, EGFR and erbB2. ZM323881 inhibited VEGF-A-induced endothelial cell proliferation with an IC50 value of 8 nM.
ZM323881 is a selective inhibitor of VEGFR-2.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | DMSO: 10 mg/mL, clear |
| web metadata keyword.default | VEGFR-2 inhibitor ZM323881 hydrochloride IC50 2 nM,ZM-323881 hydrochloride 5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride,ZM323881 hydrochloride 193000-39-4,ZM323881 hydrochloride 5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol,ZM323881 hydrochloride for VEGF-A inhibition studies,ZM323881 hydrochloride for biomedical research,ZM323881 hydrochloride for research,ZM323881 hydrochloride for tyrosine kinase inhibition,ZM323881 hydrochloride powder for laboratory use,chemical structure ZM323881 hydrochloride for pharmacology,custom ZM323881 hydrochloride synthesis service,high purity ZM323881 hydrochloride 1g,lab-grade ZM323881 hydrochloride for endothelial cell proliferation studies,research-grade ZM323881 hydrochloride 10mg,selective VEGFR-2 inhibitor ZM323881 hydrochloride |
| storage temp. | 2-8°C |
| SMILES string | Fc1c(cc(c(c1)C)O)Nc2ncnc3c2ccc(c3)OCc4ccccc4.Cl |
| InChI | 1S/C22H18FN3O2.ClH/c1-14-9-18(23)20(11-21(14)27)26-22-17-8-7-16(10-19(17)24-13-25-22)28-12-15-5-3-2-4-6-15;/h2-11,13,27H,12H2,1H3,(H,24,25,26);1H |
| InChI key | AVRHWGLIYGJSOD-UHFFFAOYSA-N |
| 长度(mm) | |
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| 重量(kg) |
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