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6, 2′, 4′-trimethoxyflavone，50MG，T4080-50MG，Sigma

销售价： ¥ 3486.74 / 件

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订货号： 0BR9095

品牌型号： Sigma T4080-50MG

货期：询货期

最小订货量： 1件

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产品介绍 Product Description

Biochem/physiol Actions

The AHR along with immune functions, is also associated with endocrine processes and cancer development.
6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity.
6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. The role of the transcription factor aryl hydrocarbon receptor (AHR) in biology is still under evaluation and has expanded beyond that of a xenobiotic sensor and regulator of detoxification. Inhibition of AHR activity by antagonists could result in anti-inflammatory actions. 6, 2′, 4′-trimethoxyflavone (TMF) is a pure AHR antagonist. The compound compete with agonists, such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), thus effectively inhibiting AHRmediated transactivation of a heterologous reporter and endogenous targets e.g. CYP1A1. TMF also exhibits no species or promoter dependency with regard to AHR antagonism. Thus it represents an improved tool allowing for more precise dissection of AHR function.

Preparation Note

6, 2′, 4′-trimethoxyflavone is soluble in DMSO at a concentration that is greater than 5 mg/ml.

技术参数 Specifications

Quality Segment	100
assay	≥98% (HPLC)
form	powder
storage condition	desiccated,protect from light
color	yellow
solubility	DMSO: >5 mg/mL
storage temp.	room temp
SMILES string	COc1ccc(c(OC)c1)C2=CC(=O)c3cc(OC)ccc3O2
InChI	1S/C18H16O5/c1-20-11-5-7-16-14(8-11)15(19)10-18(23-16)13-6-4-12(21-2)9-17(13)22-3/h4-10H,1-3H3
InChI key	WUWFDVDASNSUKP-UHFFFAOYSA-N

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