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Biochem/physiol Actions
A-278637 is a selective opener of ATP-sensitive K (KATP) channels (EC50 = 102 nM) that blocks contraction of bladder smooth muscle in both in vivo and in vitro assays. A-278637 is 15-fold more selective than nifedipine for bladder compared other smooth muscle KATP channels, and displays reduced effects on mean arterial pressure compared to other channel openers.
A-278637 is a selective opener of ATP-sensitive K (KATP) channels.
| Quality Segment | 100 |
| assay | ≥98% |
| form | powder |
| optical activity | [α]/D -44 to -54°, c = 0.1 in acetonitrile |
| color | white to beige |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
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¥ 1082.93
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¥ 1615.94
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¥ 1376.90
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¥ 3895.14
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¥ 2532.00
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¥ 1066.63
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¥ 656.88
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¥ 713.29
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¥ 839.71
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¥ 915.42
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