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General description
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1200-1300 of human NEDD4 (P46934).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| material | colorless |
| clone | 7R0M4, monoclonal |
| form | liquid |
| mol wt | 120 kDa |
| species reactivity | human |
| concentration | 0.60 mg/mL |
| technique(s) | western blot: 1:500 - 1:2000 |
| color | colorless |
| isotype | IgG |
| immunogen sequence | GDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEE |
| UniProt accession no. | P46934 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... NEDD4(4734) |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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¥ 4039.86
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¥ 2882.02
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¥ 2307.00
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¥ 1476.00
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¥ 1749.15
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¥ 1783.21
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¥ 1586.69
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¥ 5990.26
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¥ 3796.67
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