Anti-MED28 antibody produced in rabbit，100UG，SAB3501236-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

MED28 Antibody: The mediator complex is a multi-protein transcriptional co-activator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factor. One of the proteins in this complex is MED28, also known as Magicin. MED28 is expressed in many cell lines and tissues. It has been shown that a down-regulation of MED28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell differentiation and conversely its over-expression represses expression of SMC genes. MED28 can also form a ternary complex with Grb2 and Merlin, the neurofibromatosis 2 tumor suppressor protein, indicating that MED28 may play a role in Merlin′s tumor suppressive activity. MED28 has also been recently identified as an HIV dependency factor (HDF), suggesting that MED28 may be an important drug target in HIV treatment. At least two isoforms of MED28 are known to exist.

Immunogen

MED28 antibody was raised against a 17 amino acid synthetic peptide from near the center of human MED28.The immunogen is located within amino acids 50 - 100 of MED28.

Application

MED28 antibody can be used for detection of MED28 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Physical form

Supplied in PBS containing 0.02% sodium azide.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	liquid
species reactivity	mouse, human
concentration	1 mg/mL
technique(s)	immunofluorescence: suitable,immunohistochemistry: suitable,western blot: suitable
isotype	IgG
NCBI accession no.	NP_079481
UniProt accession no.	Q9H204
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... MED28(80306)

长度(mm)
宽度(mm)
高度(mm)
重量(kg)