- 商品介绍
- 规格参数
- 包装参数
General description
Human PADI2, also known as Peptidyl arginine deiminase, type II, (GenBank Accession No. NM_007365), amino acids 1-665 (end) with C-terminal FLAG-tag, MW= 77kDa, expressed in a Baculovirus infected Sf9 cell expression system. Peptidyl arginine deiminase, protein-2 (PADI2) is mapped to human chromosome 1p36. It is expressed in Sertoli cells at the time of testicular development.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. PADI-2 human has been used in in vitro binding assays.
Biochem/physiol Actions
Peptidyl arginine deiminase, protein-2 (PADI2) promotes protein citrullination and represses the multiplication of cells. It helps to transform the amino acid arginine in a protein into amino acid citrulline. PADI2 participates in epigenetic mechanisms. It is linked with rheumatoid arthritis.
Physical form
Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/uL Flag peptide, 3 mMDTT, and 20% Glycerol.
| biological source | human |
| recombinant | expressed in baculovirus infected Sf9 cells |
| assay | ≥60% (SDS-PAGE) |
| form | aqueous solution |
| mol wt | 77 kDa |
| packaging | pkg of 10 μg |
| NCBI accession no. | NM_007365 |
| UniProt accession no. | Q9Y2J8 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... PADI2(11240) |
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