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Biochem/physiol Actions
Potent and selective SETD2 inhibitor with anti-cancer efficacy.
EPZ-719 is a potent and selective SETD2 inhibitor (Ki/IC50 = 3.3/8 nM), being > 8000-fold more selective towards SETD2 over 14 other histone methyltransferases, including the mono/di-H3K36 methylases SMYD2 and WHSC1/MMSET/NSD2. EPZ-719 downregulates cellular H3K36 trimethylation level (IC50 = 23 nM, A549 cells) and shows potent anti-proliferative activity against multiple myeloma cell lines (IC50 in 14 days = 25 nM/KMS34, 11 nM/KMS211) and good pharmacokinetic properties in mice.
| Quality Segment | 100 |
| assay | ≥94% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | FC1=C2C(NC(C(N[C@H]3C[C@@H](N4C[C@H](CC4)N(C)S(C)(=O)=O)CCC3)=O)=C2)=C(C=C1)C.[0.75H2O] |
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