Anti-ESRα Antibody, clone 4L8K5, Rabbit Monoclonal,100UL,SAB5702607-100UL,Sigma

销售价: ¥ 3636.13 / 件
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订货号 0BP6144
品牌型号 Sigma SAB5702607-100UL
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.


Immunogen

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Estrogen Receptor alpha (ESRα) (P03372).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.


Application

WB, IF/ICC


技术参数 Specifications
biological sourcerabbit
Quality Segment100
conjugateunconjugated
materialcolorless
clone4L8K5, monoclonal
formliquid
mol wt 66 kDa
species reactivityhuman, rat
concentration1.33 mg/mL
technique(s)immunofluorescence: 1:50 - 1:200,western blot: 1:1000 - 1:2000
color colorless
isotypeIgG
immunogen sequenceAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFY
UniProt accession no.P03372
shipped inwet ice
storage temp.−20°C
target post-translational modificationunmodified
Gene Informationhuman ... ESR1(2099)
长度(mm)
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高度(mm)
重量(kg)
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