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Biochem/physiol Actions
AZ3146 is a potent and specific inhibitor of monopolar spindle 1 kinase (Mps1; IC50 = 35 nM), an important regulator of Spindle Assembly Checkpoint (SAC). AZ3146 treated HeLa cells override SAC, and quickly enter mitosis, with a reduced mitosis completion time of 32 minutes. 50% of treated cells entered anaphase without complete chromosomal alignment.
AZ3146 is a potent and specific inhibitor of monopolar spindle 1 kinase.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to light brown |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| web metadata keyword.default | 9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one,AZ3146 1124329-14-1 CAS number,AZ3146 IC50 35 nM Mps1 inhibitor,AZ3146 Mps1 kinase inhibitor,AZ3146 chemical structure and applications,AZ3146 effective inhibitor for anaphase research,AZ3146 for HeLa cell research,AZ3146 for cancer research,AZ3146 potent inhibitor of monopolar spindle 1 kinase,AZ3146 reagent for mitosis studies,AZ3146 spindle assembly checkpoint research chemical,Sigma-Aldrich AZ3146 reagent for spindle assembly checkpoint,Sigma-Aldrich AZ3146,laboratory-grade AZ3146 for cell cycle studies |
| storage temp. | 2-8°C |
| SMILES string | CN1CCC(OC2=CC(OC)=C(NC3=NC=C4C(N(C5CCCC5)C(N4C)=O)=N3)C=C2)CC1 |
| InChI | 1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27) |
| InChI key | YUKWVHPTFRQHMF-UHFFFAOYSA-N |
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