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General description
The PAI-1 (plasminogen activator inhibitor) gene is localized to human chromosome 7q22.1. Active form of PAI-1 is expressed in the blood and tissues. Platelets harbor both the active and latent forms of PAI-1.
This ELISA antibody pair detects mouse and human PAI-1.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
PAI-1 (plasminogen activator inhibitor) produced by platelets takes part in stabilizing blood clotting mechanism. PAI-1 prevents plasminogen activation during fibrinolysis. This might lead to the risk of cardiovascular disease. Elevated levels of PAI-1 has been observed in type 2 diabetes mellitus and serves the reason for reduced insulin sensitivity. PAI-1 stimulates the process of cellular senescence. PAI-1 regulation occurs through p53 dependent TGF-β (transforming growth factor-β) signalling. Studies also also predict that stress and depression might influence PAI-1 expression.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
| species reactivity | mouse, human |
| technique(s) | ELISA: suitable |
| assay range | inter-assay cv: <12% intra-assay cv: <10% sensitivity: 80 pg/ml |
| shipped in | wet ice |
| storage temp. | −20°C |
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