- 商品介绍
- 规格参数
- 包装参数
产品介绍
Product Description
Application
AZD-7762 hydrochloride has been used:
- as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines
- as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events
- as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development
Biochem/physiol Actions
AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2 that enhanced cytotoxicity DNA-damaging agents.
AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to light brown |
| solubility | DMSO: 15 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)-c3cccc(F)c3 |
| InChI | 1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1 |
| InChI key | WFZBLOIXZRZEDG-YDALLXLXSA-N |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
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