Anti-SARS-CoV-2 3CLpro Antibody, clone 1G8P9, Rabbit Monoclonal，100UL，SAB5701963-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

[Spike protein S1]: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. Binding to host NRP1 and NRP2 via C-terminal polybasic sequence enhances virion entry into host cell. This interaction may explain virus tropism of human olfactory epithelium cells, which express high level of NRP1 and NRP2 but low level of ACE2. The stalk domain of S contains three hinges, giving the head unexpected orientational freedom. Uses human TMPRSS2 for priming in human lung cells which is an essential step for viral entry. Can be alternatively processed by host furin. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.

Immunogen

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-306 of coronavirus 3CLpro (YP_009725295.1).

Application

WB, IF/ICC

技术参数 Specifications

biological source	rabbit
Quality Level	100
material	colorless
clone	1G8P9, monoclonal
form	liquid
mol wt	30-35 kDa
species reactivity	SARS coronavirus
concentration	1 mg/mL
technique(s)	immunofluorescence: 1:50 - 1:200,western blot: 1:500 - 1:5000
color	colorless
isotype	IgG
immunogen sequence	MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPV
UniProt accession no.	P0DTC2
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... 3CLpro(43740578)

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