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- 规格参数
- 包装参数
General description
The tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7), also known as interferon related developmental regulator 1 (FRD1), is mapped to human chromosome 7q31.1. The gene with 13 exons, spans about 52kb of genomic DNA. The encoded protein consists of 451 amino acids and is expressed in mature neutrophils.
Immunogen
synthetic peptide corresponding to amino acids 30-47 of mouse Tis7, conjugated to KLH.
Application
Monoclonal Anti-TIS7 antibody produced in mouse has been used in western blot analysis.
Biochem/physiol Actions
Tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7)/interferon related developmental regulator 1(FRD1) is implicated in regulation of the proliferation and differentiation pathways induced by nerve growth factor (NGF). The encoded protein also plays a vital role in myocyte differentiation, and it modulates the nuclear factor-κB (NF-κB) pathway by influencing the activity of histone deacetylases and forming complexes with the p65 subunit of NFκB. Genetic variations in the gene is associated with the development of various diseases such as sensory/motor neuropathy with ataxia (SMNA), cystic fibrosis, lung disease and myelodysplastic syndrome (MDS). TIS7 is also implicated in regulation of airway inflammation.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Level | 200 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | IRT537, monoclonal |
| form | buffered aqueous solution |
| mol wt | antigen ~50 kDa |
| species reactivity | mouse, human |
| concentration | ~2 mg/mL |
| technique(s) | immunocytochemistry: suitable,indirect ELISA: suitable,microarray: suitable,western blot: 0.25-0.5 using extracts of COS7 cells transfected with mouse Tis7 |
| isotype | IgG2a |
| UniProt accession no. | O00458 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... IFRD1(3475) mouse ... Ifrd1(15982) rat ... Ifrd1(29596) |
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