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Biochem/physiol Actions
RO8191 is a potent and specific type I interferon receptor agonist that directly binds to IFN-α receptor 2 (IFNAR2).
RO8191 is an imidazonaphthyridine compound, which activates interferon (IFN) signals, IFN-stimulated genes (ISGs) expression and Janus kinase (JAK)/signal transducers and activators of transcription (STAT) phosphorylation.
RO8191 is an orally available, potent and specific type I interferon receptor agonist that directly binds to IFN-α receptor 2 (IFNAR2). RO8191 suppresses HCV replication without inducing host cell toxicity.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 0.5 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| SMILES string | FC(F)(F)c1nc2[n]3c(nc(c3)c4nnc[o]4)ccc2c(c1)C(F)(F)F |
| InChI key | GRHYZVJEXKTJOS-UHFFFAOYSA-N |
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