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General description
Oxatomide, a histamine H1-receptor antagonist, is bound at high levels to plasma proteins in human blood.
Biochem/physiol Actions
Oxatomide is an anti-allergy compound. It suppresses platelet activating factor (PAF)-induced bronchoconstriction and inhibits leukotriene production.
Oxatomide, found in several antihistamines, can suppress mast cell degranulation. It can be used as an alternative to individuals with allergic rhinitis who do not or poorly respond to more established antihistamines. Oxatomide exhibits both antihistamine and anti-inflammatory properties. It exhibits therapeutic effects against asthma and vulvar lichen sclerosus.
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
| Quality Level | 100 |
| assay | ≥99% |
| form | powder |
| color | white |
| solubility | DMSO: soluble,ethanol: soluble |
| originator | Johnson & Johnson |
| SMILES string | O=C1Nc2ccccc2N1CCCN3CCN(CC3)C(c4ccccc4)c5ccccc5 |
| InChI | 1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32) |
| InChI key | BAINIUMDFURPJM-UHFFFAOYSA-N |
| Gene Information | human ... DRD3(1814) |
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¥ 1665.68
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¥ 916.08
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¥ 3593.05
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