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Biochem/physiol Actions
EN219 is a cell-permeable chloroacetamide compound that selectively inhibits E3 ligase RNF114-mediated autoubiquitination and p21 ubiquitination. EN219 is shown to covalently interact with RNF114-C8 (IC50 = 470 nM), TUBB1-C201, HSPD1-C442, and HIST1H3A-C97. EN219 is a recruiter of the E3 ubiquitin ligase RNF114 that can be utilized for PROTAC applications.
cell-permeable chloroacetamide compound that selectively inhibits E3 ligase RNF114-mediated autoubiquitination and p21 ubiquitination
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | Brc1ccc(cc1)C2N(NC(=C2)c3ccc(cc3)Br)C(=O)CCl |
| InChI key | PREWPJFURADJST-UHFFFAOYSA-N |
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¥ 2528.88
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¥ 1596.77
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¥ 2013.69
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¥ 4039.86
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¥ 4390.38
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¥ 2882.02
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¥ 2617.87
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¥ 1509.00
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¥ 1301.36
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¥ 4020.77
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