Anti-ITGAE antibody produced in rabbit，100UL，HPA036313-100UL，Sigma

General description

Integrin, α E (ITGAE, CD103) is an integrin polypeptide which combines with integrin β 7 to from the heterodimeric integrin molecule αEβ7. The primary ligand of integrin αEβ7 is the adhesion molecule E-cadherin expressed by mature epithelial cells. αEβ7 is believe to be involved in functions such as T cell homing.
Rabbit polyclonal anti-ITGAE antibody reacts with human integrin, α E (CD103).
Anti-ITGAE antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using protein array and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

Immunogen

integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) recombinant protein epitope signature tag (PrEST)

Application

Rabbit polyclonal anti-ITGAE antibody is used to tag integrin, α E (CD103) for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as immunoblotting, immunoprecipitation, and immunofluorescence. It is used as a probe to determine the presence and roles of integrin, α E (CD103) in the assembly and function of integrin αEβ7 which is involved in processes such as the binding E-cadherins.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Other Notes

Corresponding Antigen APREST77708

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.