- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1
UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively targets CBX4 and CBX7 most potently, with Kd values of ∼100 nM. The PRC1 chromodomains facilitate PRC1-mediated transcriptional repression by targeting the complex to Trimethyllysine 27 on histone 3 (H3K27me3). UNC3866 antagonizes the methyllysine (Kme) reading function, and has been shown to inhibit the PC3 prostate cancer cell proliferation associated with CBX7 overexpression.
| assay | ≥98% (HPLC) |
| form | lyophilized powder (white) |
| color | white to off-white |
| shipped in | wet ice |
| storage temp. | −20°C |
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¥ 4164.19
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¥ 2290.21
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¥ 4039.86
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmSFCA滤膜，孔径0.2um,适合瓶颈尺寸45mm，12/箱，291-4520，Nalgene，Thermofisher，赛默飞世尔¥ 2856.42
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¥ 15214.65
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¥ 1568.60
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¥ 1301.36
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¥ 4020.77
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¥ 1783.21
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¥ 954.17
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