LIGHT 来源于小鼠，20UG，SRP3217-20UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTbR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD+8 tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to active NFkB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant human LIGHT has a calculated mass of 19.3 kDa containing 177 amino acid residues. Recombinant murine LIGHT is a 20.1 kDa protein containing 183 amino acid residues.

Biochem/physiol Actions

LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTbR, or bind to a decoy receptor, DcR3. Recombinant murine LIGHT is a 20.1 kDa protein containing 183 amino acid residues.

Physical form

Lyophilized from 20mM Tris, pH 8.5 + 100 mM Arginine.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Other Notes

MRLHQRLGDI VAHLPDGGKG SWEKLIQDQR SHQANPAAHL TGANASLIGI GGPLLWETRL GLAFLRGLTY HDGALVTMEP GYYYVYSKVQ LSGVGCPQGL ANGLPITHGL YKRTSRYPKE LELLVSRRSP CGRANSSRVW WDSSFLGGVV HLEAGEEVVV RVPGNRLVRP RDGTRSYFGA FMV

技术参数 Specifications

biological source	mouse
recombinant	expressed in E. coli
assay	≥96% (HPLC),≥96% (SDS-PAGE)
form	lyophilized
mol wt	20.1 kDa
packaging	pkg of 20 μg
technique(s)	cell culture \| mammalian: suitable
impurities	<0.1 EU/μg endotoxin, tested
color	white to off-white
UniProt accession no.	Q9QYH9
shipped in	wet ice
storage temp.	−20°C
Gene Information	mouse ... TNFSF14(50930)

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