Anti-Phospho-PDPK1-S241 antibody produced in rabbit，100UL，SAB5701770-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling . Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive.

Immunogen

A synthetic phosphorylated peptide around S241 of human PDPK1 (NP_002604.1).

Physical form

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

技术参数 Specifications

biological source	rabbit
Quality Level	100
antibody product type	primary antibodies
clone	polyclonal
form	liquid
species reactivity	mouse, human, rat
concentration	0.57 mg/mL
technique(s)	immunohistochemistry: 1:50-1:100,western blot: 1:500-1:2000
UniProt accession no.	O15530
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	phosphorylation (pSer241)
Gene Information	human ... PDPK1(5170)

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