- 商品介绍
- 规格参数
- 包装参数
Application
SB 657510 may be used to study the urotensin II receptor-mediated signaling.
Biochem/physiol Actions
SB 657510 is a potent and selective urotensin-II (UT) receptor antagonist.
SB 657510 slows development of diabetes-associated atherosclerosis in mouse model of diabetes.1
SB-657510 is a selective urotensin-II (UT) receptor antagonist. Human urotensin-II (hU-II) is proposed to play a significant role in cardiorenal and metabolic disease states, including heart failure, atherosclerosis, hypertension.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to off-white |
| solubility | DMSO: ≥30 mg/mL |
| originator | GlaxoSmithKline |
| storage temp. | room temp |
| SMILES string | COc1cc(Br)c(cc1OC)S(=O)(=O)Nc2ccc(Cl)c(O[C@@H]3CCN(C)C3)c2 |
| InChI | 1S/C19H22BrClN2O5S/c1-23-7-6-13(11-23)28-16-8-12(4-5-15(16)21)22-29(24,25)19-10-18(27-3)17(26-2)9-14(19)20/h4-5,8-10,13,22H,6-7,11H2,1-3H3/t13-/m1/s1 |
| InChI key | KQCZCINJGIRLCD-CYBMUJFWSA-N |
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