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Biochem/physiol Actions
L6H21 is an orally bioavailable chalcone that acts as a myeloid differentiation factor 2 (MD2) antagonist and shows a great inhibitory effect on pro-inflammatory cytokines expression levels. L6H21 binds to the hydrophobic pocket of MD2 in a dose-dependent manner with a high affinity (Kd = 33.3 µM) and inhibits the ability of LPS to recognize TLR4/MD2 complex. Suppresses NLRP3 inflammasome activation and may serve as a potential candidate for the treatment of allograft rejection.
Orally bioavailable chalcone that acts as a myeloid differentiation factor 2 (MD2) antagonist
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
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¥ 1866.29
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¥ 2666.57
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