- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of RB protein leading to an active transcriptional repression of E2F complex.CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
| recombinant | expressed in baculovirus infected Sf9 cells |
| Quality Level | 200 |
| product line | PRECISIO® Kinase |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| specific activity | 12-16 nmol/min·mg |
| mol wt | CDK4 subunit ~57 kDa,cyclin D1 ~61 kDa |
| UniProt accession no. | P11802,P24385 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... CCND1(595), CDK4(1019) |
| 长度(mm) | |
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| 重量(kg) |
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询价
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¥ 1665.68
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¥ 503.76
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¥ 2355.14
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¥ 1376.90
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¥ 1260.99
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¥ 95.27
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¥ 1958.88
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¥ 5762.83
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¥ 907.59
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¥ 1147.95
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¥ 1390.75
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NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔询价
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¥ 66743.99
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