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Biochem/physiol Actions
Dimethylaminoparthenolide (DMAPT) is a water-soluble analogue of parthenolide that exhibits anti-inflammatory and anti-tumor activities. It directly binds to ribosomal protein L10 (RPL10) leading to decrease the expression of either p65 or IKKγ in varies pancreatic cancer cells. Dimethylaminoparthenolide radiosensitizes non-small-cell lung carcinoma (NSCLC) by inhibition of the canonical NF-κB pathway.
Water-soluble analogue of parthenolide that exhibits anti-inflammatory and anti-tumor activities
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | C/C1=C\CC[C@](O2)(C)[C@@]2([H])[C@@H](OC([C@@H]3CN(C)C)=O)[C@@]3([H])CC1 |
| InChI key | UJNSFDHVIBGEJZ-SQJADDCJSA-N |
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¥ 1259.40
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¥ 145427.01
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¥ 57595.03
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