- 商品介绍
- 规格参数
- 包装参数
General description
Breast cancer type 2 susceptibility protein (BRCA2), DNA repair associated gene is located on human chromosome 13q13.1. BRCA2 and BRCA1 colocalize in subnuclear foci in somatic cells and on the axial elements of developing synaptonemal complexes.
Immunogen
BRCA2 (NP_000050, 3319 a.a. ~ 3418 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
SPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI
Biochem/physiol Actions
Breast cancer type 2 susceptibility protein (BRCA2), DNA repair associated protein encodes a protein that promotes homologous recombination, which is essential for normal development. Mutations causes tumor formation and cell lethality. Bi-allelic mutations of BRCA2 is associated with Fanconi anemia (FA). BRCA2 alterations can be used as a prognostic marker for pancreatic cancer.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 3D12, monoclonal |
| form | buffered aqueous solution |
| species reactivity | human |
| technique(s) | indirect ELISA: suitable,western blot: 1-5 μg/mL |
| isotype | IgG3κ |
| GenBank accession no. | NM_000059 |
| UniProt accession no. | P51587 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... BRCA2(675) |
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¥ 12156.68
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¥ 2290.21
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¥ 3442.25
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¥ 6894.69
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¥ 1653.62
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¥ 3335.66
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¥ 3319.60
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¥ 787.34
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¥ 8072.66
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