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General description
MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3. It is upregulated in neurons but is most prominent in axons.
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Immunogen
Peptide sequence around aa. 354-358 (I-G-S-L-D), according to the protein MAPT.
Biochem/physiol Actions
Removal of MAPT results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | ~48 kDa, ~62 kDa, ~78 kDa |
| species reactivity | human, mouse, rat |
| concentration | 1 mg/mL |
| technique(s) | indirect immunofluorescence: 1:100-1:200 |
| isotype | IgG |
| immunogen sequence | (I-G-S-L-D) |
| NCBI accession no. | NP_001116538.1 |
| UniProt accession no. | P10636 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... MAPT(4137) |
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