CD88 (C5AR)-VioBright 515, mouse,130-123-195,美天旎

销售价: ¥ 2724.43 / 件
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订货号 6PY4847
品牌型号 美天旎 130-123-195
货期 询货期
最小订货量 1件
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产品介绍 Product Description

Clone REA1206 recognizes the mouse CD88 antigen, a 43 kDa G type protein–coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 is expressed on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on microglia and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist.

Additional information: Clone REA1206 displays negligible binding to Fc receptors.


Alternative names

C5AR1, C5a-R, C5AR, C5R1


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