- 商品介绍
- 规格参数
- 包装参数
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规格 |
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| Accession Number: | NP_004295.2 |
| Protein Form: | Recombinant, Active, Catalytic |
| Shipping Condition: | Dry Ice |
| Molecular Weight: | 88.9 kDa |
| Validated Application: | Kinase Assay |
| Expression System: | Insect |
| KinaseFamily: | Insulin & IGF Receptors |
| Protein Length: | aa 1060 - end |
| Protein Tag: | GST Tag |
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储存 |
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| Storage Buffer: 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol |
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描述 |
This ALK T1151_L1152insT recombinant human protein (1060–end) was expressed in insect cells. ALK receptor tyrosine kinase or anaplastic lymphoma kinase was originally identified as a member of the insulin receptor subfamily that acquires transforming capability when truncated and fused to NPM (nucleophosmin) in the t(2;5) chromosomal rearrangement associated with ALCL. Many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types. In the nervous system, ALK in the presence of ligand appears essential for axonal guidance, whereas in the absence of ligand, ALK expression can lead to developmental neuronal apoptosis. ALK T1151_L1152insT recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
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