CD47-APC, human, REA220, 100 tests，130-123-254，美天旎

Clone REA220 recognizes CD47, a heavily glycosylated protein with an extracellular IgV domain, five transmembrane domains, and a cytoplasmic tail, which exists in four different isoforms. CD47 interact with integrins, thrombospondin-1 (TSP-1), and cell surface gylcoproteins SIRPα and SIRPβ. Owing to these interactions, CD47 plays an important role in lymphocyte homeostasis, maturation and activation of dendritic cells, cellular transmigration, and phagocytosis of cells. Expression of CD47 is found ubiquitously.

Additional information: Clone REA220 displays negligible binding to Fc receptors.

Integrin-associated protein, IAP, MER6, OA3, CD47

Technical specifications