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General description
Poly(oligoethylene glycol methacrylate) (POEGMA), is a comb-shaped, graft copolymer consisting of hydrophilic oligomer PEG chains grafted to a hydrophobic polymethacrylate backbone. POEGMA has been suggested as a viable alternative to poly (ethylene glycol) (PEG) in biological and biomaterial applications. POEGMA has been reported to improve pharmacokinetic properties of protein and peptide conjugates,PMID 20810920PMID 24911529 enhance the stability and gene silencing efficiency of siRNAs,PMID 21480423 as an anti-fouling surface for biosensors,PMID 25170805 and eliminate PEG antigenicity.PMID 19706892PMID 28777555 In addition to use in biomolecule-polymer conjugates, PEOGMA has also seen wide spread use in tissue engineering applications, such as hydrogel synthesis. Hydrazide-functionalized POEGMA can be readily used with the corresponding aldehyde-functionalized POEGMA for rapid gelation via reversible hydrazone bond formation.PMID 24531402 Due to the reversibility of the bond formation and the low viscosity of the precursors, resulting hydrogels can be used as injectable tissue engineering matrices, local drug delivery vehicles for small molecules, or as joint lubricants. In addition, the physical properties of the resulting hydrogels, such as LCST, gelation rates, swelling kinetics, degradation kinetics, and mechanical properties, can all be readily controlled by solution concentration and the ratios of each solution.PMID 26648556
Preparation Note
This product is provided as a 25 wt% solution in water, ready to be diluted for your specific application. Please see the technical bulletin on the product page for dilution and hydrogel preparation instructions.
| form | solution |
| mol wt | ~20,000 g/mol |
| color | clear colorless to pale yellow |
| functional group | hydrazide |
| storage temp. | 2-8°C |
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¥ 1665.68
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¥ 629.40
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¥ 2290.18
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¥ 1153.44
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