- 商品介绍
- 规格参数
- 包装参数
Application
Protein degrader building block BocA1V2PF2-NHPEG3-NH2 enables the synthesis of molecules for targeted protein degradation and SNIPER (specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein erasers) technology. Developed in partnership with ComInnex, this conjugate contains an in silico-derived IAP-recruiting ligand, an alkyl-chain crosslinker, and a pendant amine for reactivity with an acid on a target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and protein degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, including CRBN and VHL targeted, parallel synthesis can be used to more quickly generate SNIPER and PROTAC® degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight.
Building blocks in this series:
917974 BocA1V2PF2
917443 BocA1V2PF2-NHC6-NH2
917699 BocA1V2PF2-NHC10-NH2
917958 BocA1V2PF2-NHPEG1-NH2
916692BocA1V2PF2-NHPEG3-NH2
Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands
Other Notes
In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)
SNIPERs−Hijacking IAP activity to induce protein degradation
E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
| ligand | BocA1V2PF2 |
| Quality Segment | 100 |
| assay | ≥95% |
| form | powder |
| reaction suitability | reactivity: carboxyl reactive,reagent type: ligand-linker conjugate |
| technique(s) | targeted protein degradation: suitable |
| functional group | amine |
| storage temp. | 2-8°C |
| SMILES string | C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCCOCCOCCOCCN)=O)CC2=CC=C(C=C2)F)=O)=O)C3CCCCC3)=O |
| InChI key | KQXJJRPJQMDBNZ-NYKRYVCLSA-N |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
¥ 3683.17
-
询价
-
询价
-
¥ 1376.90
-
询价
-
¥ 6085.86
-
询价
-
¥ 1029.59
-
¥ 1334.26
-
¥ 1327.84
-
¥ 968.94
-
¥ 633.78
-
¥ 2005.84
-
NALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/8 x 1/4 x 1/16，英寸，每箱数量50，50/箱，8000-0020，Thermofisher，赛默飞世尔询价
-
询价
-
¥ 8072.66
-
¥ 17652.29
-
¥ 58184.19
-
¥ 108621.02
-
¥ 25801.21
微信小程序
7X24小时在线咨询