- 商品介绍
- 规格参数
- 包装参数
General description
~45 kDa observed. Uniprot describes 5 isoforms produced by alternative splicing at ~45, ~42, ~37, ~35, and ~28 kDa
CLN3 protein is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs).
Immunogen
KLH-conjugated linear peptide corresponding to human CLN3.
Application
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
This Anti-CLN3 Antibody, Clone 2B8.2 is validated for use in Western Blotting and Immunohistochemistry for the detection of CLN3.
Western Blotting Analysis: 2.0 µg/mL from a representative lot detected CLN3 in 10 µg of A431 cell lysate.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected CLN3 in rat cerebellum and human thalamus tissue.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in HepG2 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected CLN3 in 10 µg of HepG2 cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 2B8.2, monoclonal |
| species reactivity | mouse, human |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_000077 |
| UniProt accession no. | Q13286 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... CLN3(1201) |
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