- 商品介绍
- 规格参数
- 包装参数
General description
A cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50 = 20 µM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 µM, but at higher concentration (~100 µM) it reversibly reduces K+ currents.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Grand, T., et al. 2008. Brit. Journ. Pharm.153, 1697.
Simard, C., 2012. Brit. Journ. Pharm.165, 2354.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | brown |
| solubility | DMSO: 50 mg/mL |
| shipped in | wet ice |
| storage temp. | 2-8°C |
| SMILES string | Oc1c2c(c3c(c1)cccc3)cccc2 |
| InChI | 1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H |
| InChI key | DZKIUEHLEXLYKM-UHFFFAOYSA-N |
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¥ 807.83
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¥ 2355.14
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¥ 3895.14
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¥ 2532.00
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¥ 860.58
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¥ 907.59
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¥ 478.46
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¥ 2024.55
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¥ 634.68
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¥ 852.85
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