- 商品介绍
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General description
A cell-permeable, irreversible inhibitor of the trypsin-like, chymotrypsin-like, and peptidylglutamyl peptide hydrolysis activities of the 20S proteasome. It is believed that in vitro, the natural product, Lactacystin (Cat. No. 426100), acts as a precursor for clasto-lactacystin β-lactone, and the later is the sole species that interacts with the proteasome. Inhibits the proteasome in intact cells (IC50 approximately 1 µM). clasto-Lactacystin β-lactone shows 5-10 fold greater potency than lactacystin in vitro.
A highly specific, cell-permeable, and irreversible 20S proteasome inhibitor. It is believed that in vitro, the natural product Lactacystin (Cat. No. 426100) acts as a precursor for clasto-lactacystin β-lactone and that the latter is the sole species that interacts with the proteasome.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
20S proteasome
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Rapidly hydrolyzed in aqueous buffers.
Other Notes
Corey, E.J., and Wei-Dong, Z. 1999. Chem. Pharm. Bull. 47, 1.
Dick, L.R., et al. 1997. J. Biol. Chem. 272, 182.
Dick, L.R., et al. 1996. J. Biol. Chem.271, 7273.
Fenteany, G., et al. 1995. Science268, 726.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze |
| color | white |
| solubility | DMSO: 3 mg/mL |
| web metadata keyword.default | Omuralide clasto-Lactacystin β-Lactone CAS 154226-60-5,Sigma-Aldrich clasto-Lactacystin β-Lactone,clasto-Lactacystin β-Lactone 1 µM proteasome inhibitor,clasto-Lactacystin β-Lactone 10 mg/ml solution,clasto-Lactacystin β-Lactone IC50 1 µM,clasto-Lactacystin β-Lactone NAR001 inhibitor,clasto-Lactacystin β-Lactone cell-permeable inhibitor,clasto-Lactacystin β-Lactone for cellular studies,clasto-Lactacystin β-Lactone for proteasome activity assays,clasto-Lactacystin β-Lactone proteasome inhibitor IX,clasto-Lactacystin β-Lactone protein extraction reagent,clasto-Lactacystin β-Lactone research-grade,clasto-Lactacystin β-Lactone,high purity clasto-Lactacystin β-Lactone for research |
| shipped in | ambient |
| storage temp. | −20°C |
| SMILES string | N1[C@@]2([C@@H](OC2=O)[C@H](C1=O)C)[C@@H](O)C(C)C |
| InChI | 1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1 |
| InChI key | FWPWHHUJACGNMZ-NBBQQVJHSA-N |
| 长度(mm) | |
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| 重量(kg) |
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