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General description
63 kDa calculated
Interferon alpha/beta receptor 1 (IFNAR-1) is a single-pass type I membrane protein containing three fibronectin type-III domains and is a member of the type II cytokine receptor family. IFNAR-1 serves as an interferon receptor specific to interferons alpha and beta, a family of type I interferons critical to the promotion and the linking of adaptive and innate immune response. Type I interferons all bind to a heterodimeric receptor composed of two subunits, IFNAR-1 and IFNAR-2. The binding of the type I IFNs initializes tyrosine phosphorylation for several proteins such as; IFNR alpha/beta subunits, JAKs, STAT, and TYK2 proteins.
Immunogen
Recombinant protein corresponding to the extracellular domain of mouse IFNAR-1.
Application
Anti-IFNAR-1 Antibody, clone MARI-5A3 is an antibody against IFNAR-1 for use in FC, IP, WB, NEUT.
Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Neutralizing Assay: A previous lot was used by an independent laboratory in neutralization studies. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Biochem/physiol Actions
This antibody recognizes the extracellular domain of IFNAR-1.
Physical form
Format: Purified
Analysis Note
Evaluated by Flow Cytometry in BALB/c splenocytes.
Flow Cytometry Analysis: 5 µg of this antibody detected IFNAR-1 in BALB/c splenocytes.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | MARI-5A3, monoclonal |
| species reactivity | mouse |
| technique(s) | flow cytometry: suitable,immunoprecipitation (IP): suitable,neutralization: suitable,western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_034638 |
| UniProt accession no. | P33896 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | mouse ... Ifnar1(15975) |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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