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General description
39 kDa
HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation is a marker for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
Immunogen
Epitope: Amino Acid: 228-246
Linear Peptide corresponding to human HDAC11 at amino acids 228-246.
Application
Anti-HDAC11 Antibody is a Rabbit Polyclonal Antibody for detection of HDAC11 also known as histone deacetylase 11 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Histone Modifying Proteins
Cell Cycle, DNA Replication & Repair
Western Blot (SNAP ID) Analysis: 0.5 µg/ml from a representative lot detected HDAC11 on 10 µg of human brain tissue lysate.
Biochem/physiol Actions
This antibody recognizes HDAC11.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Human brain tissue lysate
Evaluated by Western Blot in human brain tissue lysate.
Western Blot Analysis: 0.05 µg/ml of this antibody detected HDAC11 on 10 µg of human brain tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human, mouse, rat |
| technique(s) | western blot: suitable |
| NCBI accession no. | NP_079103.2 |
| UniProt accession no. | Q96DB2 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... HDAC11(79885) mouse ... Hdac11(232232) rat ... Hdac11(297453) |
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