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General description
Natriuretic peptides A (UniProt P01160; also known as Atriopeptin, Cardiodilatin, Cardiodilatin-related peptide, Cardionatrin, CDD, CDD-ANF, CDP, Natriuretic peptide precursor A, Prepronatriodilatin) is encoded by the NPPA (also known as ANF, ANP, ATFB6, ATRST2, PND) gene (Gene ID 4878) in human. Atrial natriuretic peptide (ANP), also called atrial natriuretic factor, is a cardiac hormone that reduces high blood pressure by promoting salt excretion, decreasing blood volume, and relaxing vessel tension in a receptor-dependent manner. Deficiency in either ANP or its receptor causes spontaneous hypertension in knockout mice. ANP is initially synthesized in cardiac myocytes as a 153 a.a. precursor with a signal (a.a.1-25) and a propeptide (a.a. 26-123) sequence. The removal of the signal peptide yields pro-ANP (a.a. 26-151), which is further cleaved by the transmembrane cardiac serine protease Corin to yield mature ANP (a.a. 124-151), also known as atrial natriuretic factor (ANF). ANP is a short-lived molecule partly due to its proteolytic degradation by the kidney Neprilysin, also known as neutral endopeptidase 24.11.
~17 kDa observed
Immunogen
Epitope: Propeptide (a.a. 26-123)
His-tagged recombinant protein corresponding to human Pro-Atrial Natriuretic Peptide.
Application
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
This Anti-Pro-Atrial Natriuretic Peptide Antibody, clone 11E3.9 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Pro-Atrial Natriuretic Peptide.
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected human Pro-Atrial Natriuretic Peptide in 10 µg of human heart tissue lysate.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected human Pro-Atrial Natriuretic Peptide in rat cardiac myocytes.
Biochem/physiol Actions
Expected to react with both prepro- and pro-atrial natriuretic peptide (ANP), but not mature ANP (a.a. 124-151 of prepro sequence).
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in rat heart tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected human Pro-Atrial Natriuretic Peptide protein in 10 µg of rat heart tissue lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 11E3.9, monoclonal |
| species reactivity | rat, human |
| technique(s) | immunohistochemistry: suitable (paraffin),western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_006163 |
| UniProt accession no. | P01160 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... NPPA(4878) |
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¥ 2707.32
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¥ 1563.36
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¥ 2013.69
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¥ 5887.85
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¥ 3442.25
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¥ 6330.00
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