- 商品介绍
- 规格参数
- 包装参数
General description
A pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 59 nM) with a ~590-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 35 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Wee1
Product does not compete with ATP.
Reversible: no
Target IC50: 59 nM against Wee1
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Palmer, B.D., et al. 2006. J. Med. Chem.49, 4896.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥97% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | brown |
| solubility | DMSO: 10 mg/mL,ethanol: 10 mg/mL |
| shipped in | ambient |
| storage temp. | −20°C |
| SMILES string | Clc1c(cccc1)c2c3c(c4c([n](c5c4cc(cc5)O)CCCC)c2)[c]([nH][c]3=O)=O |
| InChI | 1S/C24H19ClN2O3/c1-2-3-10-27-18-9-8-13(28)11-16(18)20-19(27)12-15(14-6-4-5-7-17(14)25)21-22(20)24(30)26-23(21)29/h4-9,11-12,28H,2-3,10H2,1H3,(H,26,29,30) |
| InChI key | HLSZACLAFZWCCS-UHFFFAOYSA-N |
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