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General description
Synaptotagmin-12 (SYT12) , also known as Synaptotagmin-12, Synaptotagmin XII, SytXII, and encoded by the gene SYT12, is an important protein involved in calcium dependent exocytosis of secretory vesicles through calcium and phospholipid binding to the C2 domain and Synaptotagmin-12 may serve as calcium sensors in the process of vesicular trafficking and exocytosis. Synaptotagmin-12 is a synaptic vesicle phosophoprotein that modulates spontaneous neurotransmitter release, but unlike other family members Synaptotagmin-12 differs from classical synaptotagmins in that it does not bind Ca(2+). In synaptic vesicles, synaptotagmin-12 forms a complex with synaptotagmin-1 that prevents synaptotagmin-1 from interacting with SNARE complexes. Synaptotagmin-12 also is an abundant synaptic vesicle protein that is important in LTP transmission. For instance, its phosphorylation by cAMP Protein Kinase is necessary for hippocampal mossy fiber LTP.
~ 47 kDa observed
Immunogen
Epitope: Cytoplasmic domain
GST-tagged recombinant protein corresponding to the cytoplasmic domain of human Synaptotagmin-12 (SYT12).
Application
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
This Anti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1 is validated for use in Western Blotting for the detection of Synaptotagmin-12 (SYT12).
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Synaptotagmin-12 (SYT12) in 200 µg of rat brain tissue lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 1B12.1, monoclonal |
| species reactivity | human, rat |
| concentration | 0.5 mg/mL |
| technique(s) | western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_001171351 |
| UniProt accession no. | Q8IV01 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... SYT12(91683) |
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