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PARP Inhibitor VIII, PJ34，5MG，528150-5MGCN，Sigma

销售价： ¥ 3015.30 / 件

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订货号： 0BW0785

品牌型号： Sigma 528150-5MGCN

货期：询货期

最小订货量： 1件

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商品介绍
规格参数
包装参数

产品介绍 Product Description

General description

A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC₅₀ = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350 ; EC₅₀ = 200 µM). Does not act as an antioxidant at higher concentrations (1 µM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H₂O(Cat. No. 528151 ).

Biochem/physiol Actions

Cell permeable: yes
EC50 = 20 nM inhibiting poly(ADP-ribose) polymerase (PARP)
Primary Target
PARP
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med.7, 255.
Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
Mabley, G.J., et al. 2001. Inflamm. Res.50, 561.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

技术参数 Specifications

Quality Segment	100
assay	≥98% (HPLC)
form	solid
manufacturer/tradename	Calbiochem^®
storage condition	OK to freeze,desiccated (hygroscopic),protect from light
color	white
solubility	water: 5 mg/mL
web metadata keyword.default	20 mM PARP Inhibitor VIII PJ34 solution,PARP Inhibitor VIII PJ34 CAS 344458-15-7,PARP Inhibitor VIII PJ34 EC₅₀ = 20 nM,PARP Inhibitor VIII PJ34,PARP inhibitor for cell studies,PARP inhibitor for in vivo models,Sigma-Aldrich PARP Inhibitor VIII PJ34,cell-permeable PARP Inhibitor PJ34,high potency PARP inhibitor PJ34,neuroprotection PARP inhibitor PJ34,phenanthridinone PARP inhibitor for stroke research,research grade PARP Inhibitor VIII PJ34,water-soluble PARP Inhibitor VIII PJ34
shipped in	ambient
storage temp.	−20°C
SMILES string	Cl.[nH]1c2c(c3c([c]1=O)cccc3)cc(cc2)NC(=O)CN(C)C
InChI	1S/C17H17N3O2.ClH/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H
InChI key	RURAZZMDMNRXMI-UHFFFAOYSA-N

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