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General description
Alpha-synuclein is encoded by the SNCA gene (also known as NACP, PARK1) in human. There are two other known synuclein family members, beta- and gamma-synuclein. Interest in synuclein research started with the discovery of alpha-synuclein mutation in several families with autosomal dominant Parkinson′s disease (PD). Alpha-synuclein is abundantly expressed in the brain and is found in a classic amyloid fibril form within the intra-neuronal Lewy body deposits of PD. The physiological function of synucleins is not well understood, but appears to involve membrane interactions, and in particular reversible binding to synaptic vesicle membranes. Contradictory evidences regarding inhibitory action of alpha-synuclein against phospholipase D (PLD) have been reported (PMID 11821392 & 19146388). Clone Syn211, Cat. No. 36-008-C detects epitope in the region from amino acid 121 to 125 and has been used together with clone LB509, Cat. No. MABN824, to characterize the digestion pattern of different forms of in vitro prepared alpha-synclulein aggregates (Guo, J.L., et al. 2013; PMID 23827677).
~15 kDa observed
Immunogen
Conjugated recombinant protein corresponding to human alpha-Synuclein.
Epitope: alpha-syn 121-125
Application
Anti-alpha-Synuclein (aa 121-125) Antibody, clone Syn211 (Ascites Free) is an antibody against alpha-Synuclein for use in Immunohistochemistry and Western Blotting.
Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected alpha-Synuclein in human cerebral cortex and human kidney tissue.
Western Blotting Analysis: A representative lot detected alpha-Synuclein in Synucleinopathy brains (Guo, J.L., et al. (2013). Cell. 154:103-117).
Physical form
Format: Purified
Preparation Note
Stable for 1 year at 2-8°Cfrom date of receipt.
Analysis Note
Evaluated by Western Blotting in human brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected alpha-Synuclein in 10 µg of human brain tissue lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
| biological source | mouse |
| Quality Segment | 100 |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | Syn211, monoclonal |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_000336 |
| UniProt accession no. | P37840 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... SNCA(6622) |
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¥ 2528.88
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¥ 6894.69
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¥ 3290.05
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