- 商品介绍
- 规格参数
- 包装参数
General description
A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca2+]i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Formyl Peptide Receptor-Like 1 (FPRL1)
Product does not compete with ATP.
Reversible: no
Target IC50: 230 nM for FPRL1 Agonist
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Bae, Y.S., et al. 2004. J. Immunol.173, 607.
H-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | lyophilized solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic) |
| color | white |
| solubility | DMSO: 5 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
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¥ 4862.67
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¥ 916.08
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¥ 625.35
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¥ 711.69
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¥ 1349.07
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¥ 661.45
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¥ 907.59
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