Anti-PTHrP Antibody, clone 4C4.1，100UG，MABC532，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Parathyroid hormone-related protein (UniProt P12272; also known as Parathyroid hormone-like related protein, Parathyroid hormone-like hormone preproprotein, PLP, PTH-related protein, PTH-rP, PTHrP) is encoded by the PTHLH (also known as BDE2, HHM, PTHR, PTHRP) gene (Entrez Gene ID 5744) in human. Parathyroid hormone-related protein is initially translated as a 177 amino acid preproprotein with an N-terminal signal sequence (aa 1-24) and a propeptide sequence (aa 25-34), which are later removed to yield the mature protein. The mature protein is further cleaved to produce PTHrP[1-34] (aa 37-70), PTHrP[1-36] (aa 37-72), PTHrP[38-94] (aa 74-130), and PTHrP[107-139] (aa 143-175; also known as Osteostatin). PTHrP is produced in a wide variety of tissues, where it acts as a paracrine or autocrine factor to regulate cellular and organ growth, development, migration, differentiation, calcium transport, survival and apoptosis.
~16/6 kDa observed. Uncharacterized band(s) may appear in some lysates.

Immunogen

GST-tagged recombinant human PTHrP lacking signal and propeptide sequence.

Application

Detect PTHLH using this mouse monoclonal Anti-PTHrP Antibody, clone 4C4.1, Cat. No. MABC532, validated for use in Western Blotting.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blotting in MCF-7 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected PTHrP in 10 µg of MCF-7 cell lysate.

Other Notes

Concentration: Please refer to lot specific datasheet.

技术参数 Specifications

biological source	mouse
Quality Segment	100
conjugate	unconjugated
antibody form	purified immunoglobulin
antibody product type	primary antibodies
clone	4C4.1, monoclonal
species reactivity	human
technique(s)	western blot: suitable
isotype	IgG1κ
NCBI accession no.	NP_945316
UniProt accession no.	P12272
shipped in	wet ice
target post-translational modification	unmodified
Gene Information	human ... PTHLH(5744)

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