- 商品介绍
- 规格参数
- 包装参数
General description
Etomoxir (ETO), an irreversible inhibitor of carnitine palmitoyltransferase I (CPT1), primarily impacts fatty acid oxidation. It is an epoxide-based medium-chain fatty acid used to study the biological effects of mitochondrial fatty acid β-oxidation. ETO shifts energy metabolism from fatty acids to glucose oxidation. Its mechanism of action involves reducing the transport of non-esterified fatty acids (NEFA) into the mitochondrial matrix, which subsequently reduces the substrate available for β-oxidation.
Application
Etomoxir has been used in:
- the evaluation of long-chain fatty acid respiration in neonatal mouse cardiomyocytes using SeaHorse instrument
- cell stimulation experiments to study its effects on fatty acid oxidation in metabolic syndrome-associated synoviocytes
- Seahorse assays to assess fatty acid oxidation in cultured cells by inhibiting carnitine palmitoyltransferase I (CPT1)
Other Notes
由于该运输中有害物质的性质，您的订单可能需要支付额外的运输费用。某些尺寸的产品可免除其他有害材料的运输费用。请与您当地的销售办事处联系，以获取有关这些费用的更多信息。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有毒（F）
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | white |
| solubility | DMSO: 50 mg/mL (or water) |
| shipped in | wet ice |
| storage temp. | 2-8°C |
| SMILES string | [Na+].Clc1ccc(cc1)OCCCCCC[C@]2(OC2)C(=O)[O-] |
| InChI | 1S/C15H19ClO4.Na/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;/h5-8H,1-4,9-11H2,(H,17,18);/q;+1/p-1/t15-;/m1./s1 |
| InChI key | RPACBEVZENYWOL-XFULWGLBSA-M |
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