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General description
PAR-4 is a pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells and sensitizing the cells to diverse apoptotic stimuli causing tumor regression. PAR-4 also seems to be a transcriptional repressor and is involved in regulating APP expression and the cleavage activity of BACE1. PAR-4 interacts with several proteins including WT1, but also various kinases, and structural proteins like Actin, BACE1, SPSB1, SPSB2, and SPSB4. PAR4 is localized in the cytoplasm in non-apoptotic cells but is nuclear localized in cancer and apoptotic cells. PAR-4 is widely expressed and elevated in neurodegenerative diseases such as ALS, Alzheimer, Parkinson and Huntington diseases as well as stroke. PAR-4 is down regulated in cancers.
~45 kDa observed. The calculated molecular weight is 36 kDa, however PAR-4 has been shown as a ~45 kDa band in some western blots (Masters, S.L., et al. (2006). Nature Structural & Mole. Biol. 13(1):77-84).
Immunogen
Epitope: C-terminus
GST-tagged recombinant protein corresponding to the C-terminus of human PAR-4.
Application
Anti-PAR-4 Antibody is an antibody against PAR-4 for use in Western Blotting.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in Y-79 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected PAR-4 in 10 µg of Y-79 cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | bovine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), canine (based on 100% sequence homology), horse (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no. | NP_002574 |
| UniProt accession no. | Q96IZ0 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... PAWR(5074) |
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