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Pamidronate, Disodium Salt，10MG，506600-10MGCN，Sigma

销售价： ¥ 1413.43 / 件

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订货号： 0BV9065

品牌型号： Sigma 506600-10MGCN

货期：询货期

最小订货量： 1件

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商品介绍
规格参数
包装参数

产品介绍 Product Description

General description

A calcium metabolism regulator. A potent and specific inhibitor of bone resorption at doses devoid of any significant detrimental effect on bone growth and mineralization. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget′s disease, hypercalcemia of malignancy, osteolytic bone metastasis, and steroid-induced cell death in vitro. Provided in a hydrated form containing five molecules of water.
A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget’s disease, hypercalcaemia of malignancy, osteolytic bone metastasis, steroid-induced osteoporosis, and idiopathic osteoporosis. Inhibits breast cancer cell growth by inducing cell death in vitro. Provided in hydrated form, contains five molecules of water.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Inhibitor of bone resorption
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Fromigue, O., et al. 2000. J. Bone Miner. Res.15, 2211.
Fitton, A., and McTravish, D. 1991. Drugs41, 289.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

技术参数 Specifications

Quality Segment	100
description	Merck USA index - 14, 7003
assay	≥98% (HPLC)
form	solid
manufacturer/tradename	Calbiochem^®
storage condition	OK to freeze,desiccated (hygroscopic)
color	white
solubility	water: 10 mg/mL
shipped in	ambient
storage temp.	−20°C
SMILES string	[Na+].[Na+].[P](=O)([O-])([O-])[C@@]([P](=O)([O-])O)(O)CC[N+H3].O.O.O.O.O
InChI	1S/C3H11NO7P2.2Na.5H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;;;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;51H2/q;2+1;;;;;/p-2
InChI key	CZYWHNTUXNGDGR-UHFFFAOYSA-L

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