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- 规格参数
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General description
Regulator of G-protein signaling 11 (RGS11) is a multidomain GTPase containing one each of DEP, RGS, and G-protein gamma domains. Like other members of the R7 RGS family, RGS11 uses these domains to form multisubunit complexes, which process the light responses of retinal cells. RGS11 interacts with the RGS9 anchor protein (R9AP) and the 5 G-protein beta subunit (Gbeta5) to form a trimeric complex that regulates the activity of the metabotropic glutamate receptor 6 (mGluR6) in ON-bipolar cells. The RGS11 complex hydrolyzes GTP and inactivates the G-protein Galphao, which is activated by mGluR6 in dark environments. By this mechanism, the RGS11 complex accelerates the light response in ON-bipolar retinal cells.
~53 kDa observed
Immunogen
Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of human RGS11.
Application
Detect RGS11 (C-terminus) using this Anti-RGS11 (C-terminus) Antibody validated for use in Western Blotting.
Research Category
Neuroscience
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
Biochem/physiol Actions
This antibody recognizes the C-terminus of RGS11.
Physical form
Format: Purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Human placenta tissue lysate
Evaluated by Western Blot in human placenta tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected RGS11 in 10 µg of human placenta tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 300 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| species reactivity | human, rat |
| technique(s) | western blot: suitable |
| NCBI accession no. | NP_003825 |
| UniProt accession no. | O94810 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... RGS11(8786) |
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NALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/8 x 1/4 x 1/16，英寸，每箱数量50，50/箱，8000-0020，Thermofisher，赛默飞世尔
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