- 商品介绍
- 规格参数
- 包装参数
General description
68 kDa
Polo-like Kinase 1 (PLK1) is a serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Expressed PLK protein accumulates to a maximum during the G2 and M phases, declines to a nearly undetectable level following mitosis and throughout G1 phase, and then begins to accumulate again during S phase.
Immunogen
KLH-conjugated linear peptide corresponding to human phosphoylated PLK1 at and around Ser137.
Application
Detect phospho-PLK1 (Ser137) using this Anti-phospho-PLK1 (Ser137) Antibody validated for use in WB.
Research Category
Signaling
Research Sub Category
Kinases & Phosphatases
Western Blot (SNAP ID) Analysis: 0.5 µg/mL of this antibody detected PLK1 phosphorylated at Ser137 in human placenta tissue lysate.
Biochem/physiol Actions
This antibody recognizes phosphorylated PLK1 at Ser137.
Physical form
Affinity purified
Affinity purified rabbit serum in 0.1M Tris-Glycine (pH7.4), 150mM NaCl with 0.05% sodium azide.
Preparation Note
Maintain refrigerated at 2-8°C for up to 12 months.
Analysis Note
Control
Lambda phosphatase treated and untreated human placenta tissue lysate.
Evaluated by Western Blot in human placenta tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected PLK1 phosphorylated at Ser137 in lambda phosphatase treated and untreated human placenta tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human, mouse, rat |
| species reactivity (predicted by homology) | bovine |
| technique(s) | western blot: suitable |
| NCBI accession no. | NP_005021 |
| UniProt accession no. | P53350 |
| shipped in | wet ice |
| target post-translational modification | phosphorylation (pSer137) |
| Gene Information | human ... PLK1(5347) |
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