- 商品介绍
- 规格参数
- 包装参数
General description
A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM) compared to Metastin (Cat. No. 445885).
Biochem/physiol Actions
Cell permeable: no
Primary Target
AXOR12 and hOT7T175
Product does not compete with ATP.
Reversible: no
Target Ki: 42 pM for AXOR12 and hOT7T175
Packaging
Packaged under inert gas
Other Notes
H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
Kotani, M., et al. 2001. J. Biol. Chem.276, 34631.
Ohtaki, T., et al. 2001. Nature411, 613.
Muir, A.I., et al. 2001. J. Biol. Chem.276, 28969.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥97% (HPLC) |
| form | lyophilized solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic) |
| color | white |
| solubility | DMSO: 5 mg/mL |
| shipped in | ambient |
| storage temp. | −20°C |
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| 重量(kg) |
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