- 商品介绍
- 规格参数
- 包装参数
General description
LST1, also known as Leukocyte-specific transcript 1 protein, Protein B144, and encoded by the gene LST1/B144, is an interesting protein expressed in many tissues in both the developing fetus as well as the adult. Over-expression induces morphological changes in many cells types that include the production of filopodia and microspikes. LST1 is also involved in dendritic cell maturation and also has anti-proliferation activity on lymphocyte proliferation. LST1 is localized to internal and Golgi membranes and is primarily a single-pass membrane bound protein. Recent research also demonstrates that LST1 is important for the assembly of tunneling nanotubes, a recently discovered new mechanism of cell-cell communication. LST1 induces nanotube formation by recruiting the small GTPase RalA to the plasma membrane and promoting its interaction with the exocyst complex. Furthermore, LST1 recruits the actin-crosslinking protein filamin to the plasma membrane and interacts with M-Sec, myosin and myoferlin, and this suggests a molecular model for nanotube generation and LST1’s essential role in their formation and maintenance.
~26 kDa observed. The target is universal expressed, not leukocytes specific LST1 forms dimers through disulfide bridges.
Immunogen
His-tagged recombinant protein corresponding to human LST1.
Application
Anti-LST1 antibody, clone 7E2 detects level of LST1 & has been published & validated for use in LST1.
Research Category
Inflammation & Immunology
Research Sub Category
Immunological Signaling
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected LST1 in 10 µg of human brain, human lung, human liver, human kidney, human skin, human spleen, human thymus, human pancreas, human ovary, human testis, human small intestine, human parathyroid, and human adrenal gland tissue lysate.
Western Blotting Analysis: A representative lot detected LST1 in HeLa cell lysate (Schiller, C., et al. (2009). Hybridoma. 28(4):281-286).
Physical form
Format: Purified
Protein G Purified
Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in human heart tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected LST1 in 10 µg of human heart tissue lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rat |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | 7E2, monoclonal |
| species reactivity | human |
| concentration | 1 mg/mL |
| technique(s) | western blot: suitable |
| isotype | IgG2bκ |
| NCBI accession no. | NP_001160010 |
| UniProt accession no. | O00453 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... SLCO1B1(10599) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
¥ 2528.88
-
¥ 2290.21
-
询价
-
询价
-
询价
-
询价
-
¥ 6330.00
-
询价
-
¥ 20380.83
-
NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔
询价
-
询价
-
询价
-
¥ 8072.66
-
询价
-
询价
-
¥ 39793.68
-
¥ 25008.19
-
询价
-
询价
-
询价
微信小程序
7X24小时在线咨询